Clara cells drive eosinophil accumulation in allergic asthma
نویسندگان
چکیده
منابع مشابه
Therapeutic Targeting of Eosinophil Adhesion and Accumulation in Allergic Conjunctivitis
Considerable evidence indicates that eosinophils are important effectors of ocular allergy. Increased worldwide prevalence of allergic eye pathologies has stimulated the identification of novel drug targets, including eosinophils and adhesion molecules. Accumulation of eosinophils in the eye is a key event in the onset and maintenance of allergic inflammation and is mediated by different adhesi...
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BACKGROUND Allergic rhinitis is a common disease, in which some patients will deteriorate or develop asthma. It is important to characterize these patients, thereby offering the possibility for prevention. This study evaluated eosinophil parameters as potential indicators of deteriorating allergic airway disease. METHODS The subjects of the study included all patients who suffered seasonal al...
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Asthma is a chronic inflammatory condition of the airways characterized by reversible airway obstruction, airway hyperresponsiveness (AHR) to normally harmless stimuli and airway inflammation. Eosinophilic asthma is a phenotype of the condition characterized by increased blood or sputum eosinophils whose numbers correlate with disease severity. Release of their potent pro-inflammatory arsenal b...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2011
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00197810